Symbol
Name
ID

Itch
itchy, E3 ubiquitin protein ligase
MGI:1202301

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Mouse Phenotypes

immune system phenotype

increased regulatory T cell apoptosis

enlarged spleen

increased spleen weight

abnormal lymphopoiesis

abnormal T-helper 2 cell differentiation

increased eosinophil cell number

decreased CD4-positive, alpha-beta T cell number

increased CD4-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta T cell number

increased regulatory T cell number

increased leukocyte cell number

abnormal immunoglobulin level

increased IgA level

increased IgE level

increased IgG1 level

abnormal T-helper 2 physiology

abnormal regulatory T cell physiology

enlarged lymph nodes

abnormal lymph organ size

abnormal interleukin secretion

increased interleukin-10 secretion

increased interleukin-13 secretion

increased interleukin-17 secretion

increased interleukin-4 secretion

increased interleukin-5 secretion

increased inflammatory response

lung inflammation

dermatitis

Availability

Mouse Genotype

Itch^{tm1b(EUCOMM)Hmgu}/Itch^{tm1b(EUCOMM)Hmgu}

Itch^tm1.1Alta/Itch^tm1.1Alta
Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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